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Hiroaki Matsuoka Selected Research

Nephrosclerosis

9/2008Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.
9/2007Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1).
5/2007Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats.
9/2004Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats.
7/2004Imidapril improves L-NAME-exacerbated nephrosclerosis with TGF-beta 1 inhibition in spontaneously hypertensive rats.
5/2002Nipradilol prevents L-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR.

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Hiroaki Matsuoka Research Topics

Disease

34Hypertension (High Blood Pressure)
01/2015 - 01/2002
25Heart Failure
05/2009 - 09/2002
18Fibrosis (Cirrhosis)
09/2010 - 03/2002
14Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
08/2007 - 03/2002
10Essential Hypertension
11/2013 - 10/2002
10Proteinuria
01/2010 - 07/2004
8Stroke (Strokes)
01/2015 - 09/2004
8Wounds and Injuries (Trauma)
05/2010 - 04/2005
8Cardiomegaly (Heart Hypertrophy)
03/2007 - 10/2002
6Nephrosclerosis
09/2008 - 05/2002
6Hypertrophy
08/2007 - 10/2002
6Renal Insufficiency (Renal Failure)
06/2007 - 06/2002
5Ventricular Tachycardia
01/2009 - 01/2004
5Myocardial Infarction
03/2007 - 01/2004
5Cardiovascular Diseases (Cardiovascular Disease)
03/2007 - 02/2003
5Atherosclerosis
04/2005 - 05/2002
4Inflammation (Inflammations)
09/2010 - 05/2006
3Isolated Systolic Hypertension
01/2017 - 09/2004
3Diabetes Mellitus
11/2013 - 03/2005
3Chronic Renal Insufficiency
11/2013 - 11/2005
3Diabetic Nephropathies (Diabetic Nephropathy)
01/2013 - 09/2006
3Type 2 Diabetes Mellitus (MODY)
01/2013 - 06/2003
3Ureteral Obstruction
09/2010 - 01/2006
3Hyperuricemia
11/2009 - 08/2007
3Cardiac Arrhythmias (Arrythmia)
01/2009 - 02/2005
3Malignant Hypertension
09/2007 - 07/2002
3Pheochromocytoma
09/2006 - 11/2002
3Body Weight (Weight, Body)
05/2006 - 10/2004
3Genetic Predisposition to Disease (Genetic Predisposition)
09/2004 - 02/2003
2Coronary Disease (Coronary Heart Disease)
04/2009 - 03/2003
2Hypokalemia
08/2007 - 07/2003
2Glomerulonephritis
07/2007 - 06/2003
2Hyperkalemia
06/2007 - 11/2005
2Sclerosis
01/2006 - 07/2004

Drug/Important Bio-Agent (IBA)

19AdrenomedullinIBA
05/2009 - 06/2002
12Messenger RNA (mRNA)IBA
12/2008 - 12/2002
11Antihypertensive Agents (Antihypertensives)IBA
10/2011 - 09/2004
10Angiotensin Receptor AntagonistsIBA
01/2015 - 09/2004
10SaltsIBA
02/2009 - 09/2002
9DiureticsIBA
01/2015 - 01/2002
9CreatinineIBA
01/2013 - 07/2004
8Valsartan (Vals)FDA Link
01/2017 - 07/2004
8rho-Associated KinasesIBA
09/2010 - 09/2002
8CollagenIBA
09/2010 - 01/2002
8AldosteroneIBA
05/2010 - 02/2005
8Atrial Natriuretic Factor (ANF)IBA
05/2009 - 01/2002
6Calcium Channel Blockers (Blockers, Calcium Channel)IBA
01/2015 - 04/2005
6Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)IBA
11/2013 - 04/2005
6Amlodipine (Norvasc)FDA LinkGeneric
01/2013 - 04/2005
6Transforming Growth Factor beta (TGF-beta)IBA
09/2010 - 09/2004
6Angiotensin IIIBA
05/2010 - 05/2002
6NG-Nitroarginine Methyl Ester (L-NAME)IBA
12/2008 - 05/2002
5Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
09/2010 - 01/2002
5Losartan (Cozaar)FDA LinkGeneric
01/2009 - 07/2004
5Hydrochlorothiazide (Esidrix)FDA LinkGeneric
01/2009 - 01/2005
5NADPH Oxidases (NAD(P)H oxidase)IBA
02/2008 - 12/2002
5ReninIBA
01/2008 - 10/2002
5Transforming Growth Factor beta1 (TGF beta 1)IBA
09/2007 - 07/2004
4benidipineIBA
11/2013 - 02/2008
4candesartanIBA
02/2011 - 05/2002
4imidaprilIBA
09/2010 - 12/2002
4fasudil (AT 877)IBA
09/2010 - 09/2004
4Natriuretic PeptidesIBA
04/2009 - 04/2004
4Telmisartan (Micardis)FDA Link
01/2009 - 09/2007
4Nitric Oxide Synthase (NO Synthase)IBA
12/2008 - 05/2002
4Eplerenone (Inspra)FDA LinkGeneric
05/2007 - 02/2005
4Brain Natriuretic Peptide (Natrecor)FDA Link
08/2004 - 04/2004
3olmesartanIBA
01/2015 - 11/2009
3Pharmaceutical PreparationsIBA
11/2013 - 04/2005
3cilnidipineIBA
01/2013 - 01/2010
3C-Reactive ProteinIBA
08/2009 - 03/2003
3AngiotensinsIBA
04/2009 - 10/2002
3Spironolactone (Aldactone)FDA LinkGeneric
09/2007 - 02/2005
3NADP (NADPH)IBA
05/2007 - 12/2002
3Nicorandil (SG 75)IBA
03/2007 - 01/2004
3Peptides (Polypeptides)IBA
09/2006 - 07/2005
3Class E Scavenger Receptors (Lectin Like Oxidized Low Density Lipoprotein Receptor 1)IBA
04/2006 - 07/2004
3SodiumIBA
04/2005 - 03/2004
3Y 27632IBA
01/2005 - 05/2002
3Nitric Oxide (Nitrogen Monoxide)FDA Link
07/2004 - 11/2003
3DNA (Deoxyribonucleic Acid)IBA
06/2003 - 05/2002
2CalciumIBA
11/2013 - 04/2005
2AlbuminsIBA
01/2013 - 01/2011
2ThiazidesIBA
04/2012 - 11/2009
2Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
09/2010 - 09/2004
2efonidipineIBA
05/2010 - 07/2007
2atrial natriuretic factor receptor AIBA
04/2009 - 04/2005
2NF-kappa B (NF-kB)IBA
04/2009 - 04/2006
2Caspase 3 (Caspase-3)IBA
12/2008 - 05/2002
2Type 1 Angiotensin ReceptorIBA
12/2008 - 07/2004
2Mineralocorticoid Receptor AntagonistsIBA
05/2007 - 02/2005
2Vasopeptidase InhibitorsIBA
10/2006 - 09/2006
2Fibronectins (Fibronectin)IBA
07/2006 - 01/2005
2Oxidoreductases (Dehydrogenase)IBA
06/2006 - 10/2002
2Adenosine Triphosphate (ATP)IBA
05/2006 - 01/2004
2Indicators and Reagents (Reagents)IBA
05/2006 - 02/2003
2Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
05/2006 - 01/2004

Therapy/Procedure

26Therapeutics
01/2015 - 11/2003
6Renal Dialysis (Hemodialysis)
05/2010 - 06/2003
2Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
01/2009 - 05/2008